Supplementary Files
Keywords
Abstract
Chlorhexidine gluconate is most commonly used mouthwash in dentistry. Though infrequent, adverse reaction to the use of chlorhexidine compounds have been reported which range from teeth staining, altered taste, parotid gland swelling, mucosal erosions, anaphylaxis, and sometimes even death. Immunologic reactions which are commonly seen involve type I hypersensitivity reaction and contact stomatitis (type IV hypersensitivity reaction). Desquamative mucosal and gingival lesions have been previously observed with 0.2% of chlorhexidine compounds. This case report also involves a presentation of desquamative mucosal and gingival lesions in a patient with chlorhexidine gluconate mouthwash prescription.
References
Pemberton MN, Gibson J. Chlorhexidine and hypersensitivity reactions in dentistry. Br Dent J. 2012 Dec;213(11):547-50.
Deus FP, Ouanounou A. Chlorhexidine in Dentistry: Pharmacology, Uses, and Adverse Effects. Int Dent J. 2022 Mar 12;72(3):269.
Jamshidinia N, Saadatpour F, Arefian E, Mohammadipanah F. Augmented antiviral activity of chlorhexidine gluconate on herpes simplex virus type 1, H1N1 influenza A virus, and adenovirus in combination with salicylic acid. Arch Virol. 2023 Nov 30;168(12):302.
Pereira J. Adverse effects of using 0.12% chlorhexidine digluconate: A literature review. Mod Res Dent. 2020 Jun 23;5.
Chiewchalermsri C, Sompornrattanaphan M, Wongsa C, Thongngarm T. Chlorhexidine allergy: Current challenges and future prospects. J Asthma Allergy. 2020 Mar 9;13:127-33.
Babich H, Wurzburger BJ, Rubin YL, Sinensky MC, Blau L. An in vitro study on the cytotoxicity of chlorhexidine digluconate to human gingival cells. Cell Biol Toxicol. 1995 Apr;11(2):79-88.
Skoglund LA, Holst E. Desquamative mucosal reactions due to chlorhexidine gluconate. Int J Oral Surg. 1982 Dec;11(6):380-2.
Kotsailidi EA, Kalogirou EM, Michelogiannakis D, Vlachodimitropoulos D, Tosios KI. Hypersensitivity reaction of the gingiva to chlorhexidine: Case report and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Aug;130(2):156-160.e1.