Background: Chronic periodontitis is a highly prevalent and recurrent form of periodontal disease and locally delivered tetracycline fibres are considered to exert tremendous benefits for its treatment.
Aim: The aim of the study was to observe the clinical results of locally delivered tetracycline fibres in the treatment of chronic periodontitis.
Materials and Methods: Patients aged 35-54 years diagnosed with chronic periodontitis of both gender fulfilling the inclusion criteria were selected. A sample size of 30 was calculated and total number of 60 posterior sites were selected. These sites were divided into two sets in a split mouth design as control sites treated with SRP alone and test sites treated with SRP plus tetracycline fibres.
Results: A combination of scaling, root planing and local drug delivery in the form of tetracycline fibres resulted in added benefits in the control of chronic periodontitis on the basis of the clinical findings from this study.
Conclusion: This study further adds to the evidence that tetracycline fibres as locally delivered agent are safe and effective adjunct to scaling and root planing, and can produce significant clinical benefits when compared to scaling and root planing alone in the treatment of chronic periodontitis.
Keywords: Chronic periodontitis; local drug delivery; tetracycline.
Darveau PR, Tanner A, Page RC. The microbial challenge in periodontitis. Periodontol 2000. 1997 Jun;14:12-32.
Listgarten MA. The role of dental plaque in gingivitis and periodontitis. J Clin Periodontol. 1988 Sep;15(8):485-7.
Okuda K, Wolff L, Oliver R, Osborn J, Stoltenberg L, Bereuter J, et al. Minocycline slow-release formulation effect on subgingival bacteria. J Periodontol. 1992 Feb;63(2):73-9.
Bonito AJ, Lux L, Lohr KN. Impact of local adjuncts to scaling and root planing in periodontal disease therapy: A systematic review. J Periodontol. 2005 Aug;76(8):1227-36.
Stabholz A, Kettering J, Aprecio R, Zimmerman G, Baker PJ, Wikesjo UM. Retention of antimicrobial activity by human root surfaces after in situ subgingival irrigation with tetracycline HCl or chlorhexidine. J Periodontol. 1993 Feb;64(2):137-41.
Goodson JM, Offenbacher S, Farr DH, Hogan PE. Periodontal disease treatment by local drug delivery. J Periodontol. 1985 May;56(5):265-72.
Lindhe J, Heijl L, Goodson JM, Socransky SS. Local tetracycline delivery using hollow fiber devices in periodontal therapy. J Clin Periodontol. 1979 Jun;6 (3):141-9.
Friesen LR, Williams KB, Krause LS, Killoy WJ. Controlled local delivery of tetracycline with polymer strips in the treatment of periodontitis. J Periodontol. 2002 Jan;73(1):13-9.
Goodson JM, Cugini MA, Dent RL. Multi-center evaluation of tetracycline fiber therapy: II. Clinical response. J Periodontal Res. 1991 Jul;26(4):371-9.
Minabe M, Takeuchi K, Nishimura T, Hori T, Umemoto T. Therapeutic effects of combined treatment using tetracycline-immobilized collagen film and root planing in periodontal furcation pockets. J Clin Periodontol. 1991 May;18(5):287-90.
Radvar M, Pourtaghi N, Kinane DF. Comparison of 3 periodontal local antibiotic therapies in persistent periodontal pockets. J Periodontol. 1996 Sep;67(9):860-5.
Newman MG, Kornman KS, Doherty FM. A 6-month multi-center evaluation of adjunctive tetracycline fiber therapy used in conjunction with scaling and root planing in maintenance patients: clinical results. J Periodontol. 1994 Jul;65(7):685-91.
Flemmig TF, Weinacht S, Rudiger S, Rumetsch M, Jung A, Klaiber B. Adjunctive controlled topical application of tetracycline HCl in the treatment of localized persistent or recurrent periodontitis. Effects on clinical parameters and elastase-alpha1-proteinase inhibitor in gingival crevicular fluid. J Clin Periodontol. 1996 Oct;23(10):914-21.
Vandekerckhove BN, Quirynen M, van Steenberghe D. The use of tetracycline-containing controlled release fibers in the treatment of refractory periodontitis. J Periodontol. 1997;68:353-61.
Kinane DF, Radvar M. A six-month comparison of three periodontal local antimicrobial therapies in persistent periodontal pockets. J Periodontol. 1999 Jan;70(1):1-7.
Gonçalves C, Rodrigues RMJ, Feres-Filho EJ, Colombo AP. Clinical effects of systemic and topical tetracycline therapy on chronic periodontal disease. Braz J Oral Sci. 2004 Jan-Mar;3(8):384-9.
Sinha S, Kumar S, Dagli N, Dagli RJ. Effect of tetracycline HCl in the treatment of chronic periodontitis - A clinical study. J Int Soc Prev Community Dent. 2014 Sep;4(3):149-53.
Mehta DS, Mohammadi N. A comparative assessment of the efficacy of tetracycline fibre therapy and phase I therapy in the treatment of chronic adult periodontitis. J Indian Dent Assoc. 2000;71:207-11.
Maiden MF, Tanner A, McArdle S, Najpauer K, Goodson JM. Tetracycline fiber therapy monitored by DNA probe and cultural methods. J Periodontal Res. 1991 Sep;26(5):452-9.
Golub LM, Ramamurthy N, McNamara TF, Gomes B, Wolff M, Casino A, et al. Tetracyclines inhibit tissue collagenase activity. A new mechanism in the treatment of periodontal disease. J Periodontal Res. 1984 Nov;19(6):651-5.
Yanagimura M, Koike F, Hara K. Collagenase activity in gingival crevicular fluid and inhibition by tetracyclines. J Dent Res. 1989;68(Spec Iss):1691-3.
Golub LM, Ramamurthy NS, McNamara TF, Greenwald RA, Rifkin BR. Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs. Crit Rev Oral Biol Med. 1991;2(3):297-321.
Tonetti MS. Local delivery of tetracycline: from concept to clinical application. J Clin Periodontol. 1998 Nov;25(11 Pt 2):969-77.