Keywords
DIGO
gingivectomy
Abstract
Gingival overgrowth caused by drug is a well-documented unwanted side effect and mostly caused by Nifedipine. Newer generation calcium channel blocker, amlodipine, has been used with the increasing frequency to overcome the adverse effect of first and second generation dihydropyridine derivatives of calcium channel blocker. The pathogenesis of gingival enlargement is uncertain and the treatment is still largely limited to the maintenance of an improved level of oral hygiene and surgical removal of the overgrowth tissue. This article reports the amlodipine induced gingival enlargement and its treatment in a 60 years old hypertensive female patient.
Keywords: Amlodipine; DIGO; gingivectomy.
References
Banthia R, Jain P, Banthia P, Belludi S, Jain AK. Amlodipine- induced gingival overgrowth: a case report. J Mich Dent Assoc. 2012 Sep;94(9):48-51.
Chaubal T, Bapat R. Mulberry-Shaped Gingival Overgrowth Induced by Amlodipine and Cyclosporine. Am J Med Sci. 2017 Dec;354(6):e13.
Jorgensen MG. Prevalence of amlodipine-related gingival hyperplasia. J Periodontol. 1997 Jul;68(7):676-8.
Ellis JS, Seymour RA, Steele JG, Robertson P, Butler TJ, Thomason JM. Prevalence of gingival overgrowth induced by calcium channel blockers: a community-based study. J Periodontol. 1999 Jan; 70(1):63-7.
Seymour RA, Ellis JS, Thomason JM. Risk factors for drug-induced gingival overgrowth. J Clin Periodontol. 2000 Apr; 27(4):217-23.
Tripathi AK, Mukherjee S, Saimbi CS, Kumar V. Low dose amlodipine-induced gingival enlargement: A clinical case series. Contemp Clin Dent. 2015;6(1):107-9.
Seymour RA, Thomason JM, Ellis JS. The pathogenesis of drug-induced gingival overgrowth. J Clin Periodontol. 1996 Mar; 23(3 Pt 1):165-75.
Mavrogiannis M, Ellis JS, Seymour RA, Thomason JM. The efficacy of three different surgical techniques in the management of drug-induced gingival overgrowth. J Clin Periodontol. 2006 Sep; 33(9):677-82.
Cyclosporin, nifedipine, and gingival hyperplasia. - PubMed - NCBI [Internet]. [cited 2018 Mar 8]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/2888958
Hassell TM, Page RC, Lindhe J. Histologic evidence for impaired growth control in diphenylhydantoin gingival overgrowth in man. Arch Oral Biol. 1978; 23(5):381-4.