Amlodipine, a calcium channel blocker, used with increasing frequency as antihypertensive and anti-angina drug has been found associated with gingival enlargement. It causes unesthetic appearance and formation of new niches for periodonto-pathogenic bacteria. If severe, it causes difficulty in mastication, speech and oral hygiene maintenance. Its treatment is still largely limited to meticulous oral hygiene maintenance, drug substitution, professional scaling and root planning and surgical excision of enlarged gingival tissue. There are very few reports of amlodipine-induced gingival enlargement at a dose of 5 mg. This case report discusses amlodipine-induced gingival enlargement and its management.
Newman MG, Takei HH, Klokkevold PR, Carranza FA. Carranza's Clinical Periodontology. 12th ed. Philadelphia: Elsevier Health Sciences; 2015.
Pradhan, P. Mishra. Gingival enlargement in antihypertensive medication. J Nepal Med Assoc. 2009;48(174):149–52.
Jorgensen MG. Prevalence of amlodipine-related gingival hyperplasia. J Periodontol 1997;68(7):676–8.
Sharma A, Joshi R, Rana SR, Shrestha DB, Joshi PR, Khadka S. Amlodipine induced Gingival Overgrowth in Patients at a Tertiary Level Hospital of Nepal. J Nepal Soc Perio Oral Implantol. 2018;2(1):2-5.
Seymour RA, Thomason JM, Ellis JS. The pathogenesis of drug-induced gingival overgrowth. J Clin Periodontol. 1996 Mar;23(3):165-75.
Triveni MG, Rudrakshi C, Mehta DS. Amlodipine-induced gingival overgrowth. J Indian Soc Periodontol. 2009 Sep;13(3):160-3.
Seymour RA, Ellis JS, Thomason JM: Risk factors for drug induced gingival overgrowth. J Clin Periodontol. 2000; 27: 217–23.
Seymour RA. Calcium channel blockers and gingival overgrowth. Br Dent J. 1991;170(10):376–9.
Chesterman J, Beaumont J, Kellett M, Durey K. Gingival overgrowth: Part 2: management strategies. Br Dent J. 2017;222(3):159-65.
Mavrogiannis M, Ellis JS, Thomason JM, Seymour RA. The management of drug-induced gingival overgrowth. J Clin Periodontol. 2006;33(6):434-9.